Tag: Changes

Free Download Karen Brunssen, "The Evolving Singing Voice: Changes Across the Lifespan"
English | ISBN: 1635500435 | 2018 | 300 pages | EPUB, PDF | 9 MB + 11 MB
The Evolving Singing Voice: Changes Across the Lifespan examines how the human vocal instrument transforms from infancy through old age. Synthesis of this unique and comprehensive approach is beneficial to singers, voice teachers, and voice professionals across a broad spectrum of ages.

Free Download Biomolecules’ Conformational Changes Studied by Simulations and Enhanced Sampling
English | 2024 | ISBN: 3031706013 | 175 Pages | PDF EPUB (True) | 21 MB
This thesis illuminates the critical roles biomolecules, from small molecules to proteins, play in cellular functionality, particularly highlighting their conformational changes in response to environmental cues or binding events-a cornerstone concept in drug design as well as the manifestations of disease. It explores the conformational flexibility of small molecules and proteins, essential for predicting drug interactions and understanding biological processes. Through advanced molecular dynamics simulations and enhanced sampling techniques, this research offers unprecedented insights into the structural dynamics of three distinct biomolecular systems: the capsid assembly modulator AT130, the passenger domain of pertactin, and the SARS-CoV-2 spike protein. Each system represents a unique facet of biological complexity, underscoring the thesis’s contribution to our understanding of biomolecular behavior across various scales. Furthermore, the thesis advances the field by updating the Force Field Toolkit for improved simulation accuracy. This work not only showcases the adaptability and importance of simulation techniques in modern biological research but also paves the way for novel therapeutic strategies by deepening our understanding of biomolecular dynamics.

Free Download Dispersity, Structure and Phase Changes of Proteins and Bio Agglomerates in Biotechnological Processes by Arno Kwade, Ingo Kampen
English | PDF EPUB (True) | 2024 | 548 Pages | ISBN : 3031631633 | 167.4 MB
This book serves as a comprehensive summary of the priority program SPP 1934, which focused on understanding the dispersity, structure, and phase changes of proteins and bio-agglomerates in biotechnological processes. Through contributions from various research groups, the program explored how sensitive proteins and bio-agglomerates are affected by the process environment during fermentation, downstream processing, and formulation. It investigated these effects across three size scales: microscale, encompassing single proteins, clusters, crystals, and virus-like particles; mesoscale, focusing on cells and cell clusters; and macroscale, examining overall process dynamics. The main objective was to enhance biotechnological process chains by elucidating the mechanical, thermal, and chemical stresses that impact protein and bio-agglomerate structures. By gaining insights into these stressors, the program aimed to enable precise control measures to mitigate denaturation and unfavorable growth of proteins and cells. This compilation seeks to contribute to the optimization of biotechnological processes, facilitating advancements in various industries.

Free Download Wikinomics: How Mass Collaboration Changes Everything by Alan Sklar, Don Tapscott, Anthony D. Williams
English | April 06, 2007 | ISBN: B000P7V7E6 | 13 hours and 39 minutes | MP3 128 Kbps | 751 Mb
In just the last few years, traditional collaboration in a meeting room, on a conference call, and even in a convention center has been superseded by collaborations on an astronomical scale.
Today, encyclopedias, jetliners, operating systems, mutual funds, and many other items are being created by teams numbering in the thousands or even millions. While some leaders fear the burgeoning growth of these massive online communities, Wikinomics proves this fear is folly. Smart firms can harness collective capability and genius to spur innovation, growth, and success.
A brilliant guide to one of the most profound changes of our time, Wikinomics challenges our most deeply rooted assumptions about business and will prove indispensable to anyone who wants to understand competitiveness in the 21st century.

Free Download The Speed of Trust: The One Thing that Changes Everything (Audiobook)
English | December 28, 2008 | ASIN: B001U2MTAG | M4B@128 kbps | 12h 13m | 666.6 MB
Author and Narrator: Stephen M. R. Covey
From Stephen R. Covey’s eldest son comes a revolutionary new path towards productivity and satisfaction. Trust, says Stephen M.R. Covey, is the very basis of the new global economy, and he shows how trust-and the speed at which it is established with clients, employees and constituents-is the essential ingredient for any high-performance, successful organization.
For business leaders and public figures in any arena, The Speed of Trust offers an unprecedented and eminently practical look at exactly how trust functions in our every transaction and relationship-from the most personal to the broadest, most indirect interaction-and how to establish trust immediately so that you and your organization can forego the time-killing, bureaucratic check-and-balance processes so often deployed in lieu of actual trust.

Free Download The Little Book of Changes: A Pocket I-Ching by Peter Crisp
English | February 14, 2012 | ISBN: 9781608870684 | 176 pages | PDF | 12 Mb
The Little Book of Changes is a fresh interpretation of the I Ching, one of the oldest books in the world-recognized by both Confucians and Taoists as a fundamental work. Author Peter Crisp’s perceptive and poetic rendition reimagines the ancient philosophical text as a friendly, accessible, and modern companion.

Free Download Quantitative MRI of the Brain: Measuring Changes Caused by Disease By
2003 | 652 Pages | ISBN: 0470847212 | PDF | 12 MB
(Radiology category)"This is an exciting book, with a new approach to use of the MRI scanner. It bridges the gap between clinical research and general neuro-radiological practice. It is accessible to the clinical radiologist, and yet thorough in its treatment of the underlying physics and of the science of measurement. It is likely to become a classic." British Medical AssociationThis indispensable ‘how to’ manual of quantitative MR is essential for anyone who wants to use the gamut of modern quantitative methods to measure the effects of neurological disease, its progression, and its response to treatment. It containsboth the methodology and clinical applications, reflecting the increasing interest in quantitative MR in studying disease and its progression. The editor is an MR scientist with an international reputation for high quality research The contributions are written jointly by MR physicists and MR clinicians, producing a practical book for both the research and medical communities A practical book for both the research and medical communities "Paul Tofts has succeeded brilliantly in capturing the essence of what needs to become the future of radiology in particular, and medicine in general – quantitative measurements of disease." Robert I. Grossman, M.D. New York, University School of Medicine (from the Foreword)Content: Chapter 1 Concepts: Measurement and MR (pages 1-15): Paul S. ToftsChapter 2 The Measurement Process: MR Data Collection and Image Analysis (pages 17-54): Paul S. ToftsChapter 3 QA: Quality Assurance, Accuracy, Precision and Phantoms (pages 55-81): Paul S. ToftsChapter 4 PD: Proton Density of Tissue Water (pages 83-109): Paul S. ToftsChapter 5 T1: The Longitudinal Relaxation Time (pages 111-141): Penny A. Gowland and Valerie L. StevensonChapter 6 T2: The Transverse Relaxation Time (pages 143-201): Philip A. Boulby and Fergus J. Rugg-GunnChapter 7 D: The Diffusion of Water (pages 203-256): Claudia A.M. Wheeler?Kingshott, Gareth J. Barker, Stefan C. A. Steens and Mark A. van BuchemChapter 8 MT: Magnetization Transfer (pages 257-298): Paul S. Tofts, Stefan C. A. Steens and Mark A. van BuchemChapter 9 Spectroscopy: 1H Metabolite Concentrations (pages 299-339): Paul S. Tofts and Adam D. WaldmanChapter 10 T1?W DCE?MRI: T1?Weighted Dynamic Contrast?Enhanced MRI (pages 341-364): Geoff J. M. Parker and Anwar R. PadhaniChapter 11 T2? and T2*?W DCE?MRI: Blood Perfusion and Volume Estimation using Bolus Tracking (pages 365-412): Richard P. Kennan and H. Rolf JagerChapter 12 Functional MRI (pages 413-453): Peter Jezzard and Nick F. RamseyChapter 13 ASL: Blood Perfusion Measurements Using Arterial Spin Labelling (pages 455-473): Laura M. Parkes and John A. DetreChapter 14 Biology: The Significance of MR Parameters in Multiple Sclerosis (pages 475-499): Bruno Brochet, Klaus G. Petry and Vincent DoussetChapter 15 Spatial Registration of Images (pages 501-531): John Ashburner and Catriona D. GoodChapter 16 Volume and Atrophy (pages 533-558): Geoff J. M. Parker and Declan T. ChardChapter 17 Shape and Texture (pages 559-579): William R. CrumChapter 18 Histograms: Measuring Subtle Diffuse Disease (pages 581-610): Paul S. Tofts, Gerard R. Davies and Jamshid DehmeshkiChapter 19 The Future of qMR: Conclusions and Speculation (pages 611-617): Paul S. Tofts

Free Download Small Changes for Big Results
by Ingram, Warren
English | 2024 | ISBN: 9781776391509 | 227 pages | True EPUB | 6.17 MB

Free Download Democracy in Retrograde: How to Make Changes Big and Small in Our Country and in Our Lives (Audiobook)
English | ASIN: B0D1DDD9DJ | 2024 | 4 hours and 55 minutes | M4B@128 kbps | 274 MB
Author: Sami Sage, Emily Amick
Narrator: Nikki Massoud
A whip-smart combo of self-help and political manifesto that is perfect for anyone who wants to save our democracy but doesn’t know where to start. In today’s political climate, it’s hard not to get discouraged. Isolated, doom scrolling, lacking a sense of purpose or community…it’s easy to become overwhelmed by the dire state of American democracy and do nothing, because why try when the odds are never in our favor? At this fragile moment in history, Emily Amick, lawyer and former counsel to Senate Majority Leader Chuck Schumer, alongside New York Times bestselling author and Betches Media cofounder Sami Sage, want to reframe civic engagement as a form of self-care: an assertion of one’s values and self-respect. This book is not just about voting, but about claiming your singular place in your country and community. Democracy in Retrograde will help you learn about much more than just political action. This book will provide a new lens through which to see yourself: a new and powerful light which bridges the personal and the political. In the words of Joan Baez, action is the antidote to despair, and with this helpful guide, even if Mercury is in retrograde, our democracy doesn’t have to be.

Free Download The Speed of Trust: The One Thing that Changes Everything by Stephen M. R. Covey, Rebecca R. Merrill
English | October 17, 2006 | ISBN: 074329730X, 1416549005, ASIN: B000MGATWG | True EPUB/AZW3 | 384 pages | 0.8/1.2 MB
Stephen M. R. Covey shows how trust-and the speed at which it is established with clients, employees, and all stakeholders-is the single most critical component of a successful leader and organization.