Tag: Derived

Free Download Adipose-Derived Stem Cells
English | 2024 | ISBN: 1071637614 | 390 Pages | PDF (True) | 15 MB
Since the publication of the previous editions, there has been increased focus on the use of adipose-derived stromal/stem cells (ASC) and stromal vascular fraction (SVF) cells in three-dimensional hydrogel-based scaffolds for the development of microphysiological systems (MPS) serving as in vitro humanized assays and alternatives to in vivo pre-clinical animal models. This third edition volume discusses of the latest technology and advancements in the field of human-derived ASC and SVF. The chapters in this book are organized into four parts. Part One focuses on human ASC’s isolation, characterization, and differentiation. Part Two describes the isolation and characterization of ASC and SVF from canine, feline, and murine tissues. Part Three looks at hydrogels, scaffolds, and microphysiological systems, and Part Four talks about the new assays and applications using ASC. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Free Download The Regulatory Landscape in the EU for Dairy Products Derived from Precision Fermentation: An Analysis on the Example of Cheese by Federica Ronchetti , Laura Springer , Kai P. Purnhagen
English | PDF EPUB (True) | 2024 | 85 Pages | ISBN : 3031496914 | 3 MB
This book assesses the EU legal framework applicable to dairy products obtained through precision fermentation. It maps the authorisation and labelling requirements for these products to be placed on the EU market. It compares these provisions to those governing the food markets in the USA and Singapore, which are considered to be more innovation-friendly. At the time of writing, the precision-fermented dairy sector is still in the developmental phase, with only a few precision-fermented dairy alternatives available on the market, none of which are present in the EU. Regulatory uncertainty has been cited as significant obstacle for food business operators seeking to introduce alternative protein products in the EU. The book confirms these reports, as the current EU regulatory framework presents several legal uncertainties that are challenging for food business operators to overcome. Broadly speaking, there are two authorisation frameworks applicable to dairy products obtained through precision fermentation in the EU. The choice between these frameworks depends on the presence of genetically modified organisms (GMOs) or residues thereof in the final product. If such GMOs or residues are present, the pre-market authorisation procedure is governed by the Genetically Modified Food and Feed Regulation (GMFR). If the final product does not contain any GMOs or residues, it falls under the scope of the Novel Food Regulation (NFR), and the pre-market authorisation procedure is governed accordingly. Both of these authorisation pathways entail high regulatory requirements, which can pose challenges for the development of the precision fermentation sector. Despite the difficulty in accurately classifying products, it is crucial for food business operators to comprehend the applicable legal framework early in the product development process, given that the authorisation paths differ in their standards. In addition to pre-market authorisation requirements, companies must address labelling issues. Food labelling shall provide a basis for consumers to make informed choices in relation to the foods they consume. The primary objective of EU food labelling law is to prevent consumer deception , making it crucial for dairy products and their animal-free alternatives, to adhere to a stringent naming law as stipulated in the Common Market Organisation and specific accompanying legislation. Moreover, it is imperative to consider regulations regarding the use of health and nutrition claims, as well as labels such as "vegan" or "organic", etc. Furthermore, the labelling of novel foods and genetically modified foods may necessitate mandatory information specified in the authorisation process. The book serves as a comprehensive guideline for food business operators involved in the production of precision-fermented dairy alternatives, aiding them in navigating the intricate European regulatory landscape.

Free Download Applications ofBacillus and Bacillus Derived Genera in Agriculture, Biotechnology and Beyond by VellaichamyMageshwaran UdaiB.Singh, AnilK.Saxena, HarikeshBahadurSinghEditors
English | PDF PEUB (True) | 2024 | 275 Pages | ISBN : 9819981948 | 16.3 MB

Free Download Safety Evaluation of Biotechnologically-derived Pharmaceuticals: Facilitating a Scientific Approach By John Lipani (auth.), Susan A. Griffiths, Cyndy E. Lumley (eds.)
1998 | 200 Pages | ISBN: 9401060436 | PDF | 13 MB
Considerable investment has been made by both pharmaceutical and biotechnology companies in pharmaceutical products of biotechnology. However, because relatively few of these products have been marketed, lack of relevant experience means that uncertainty still surrounds the most appropriate strategy for their safety evaluation. The 13th CMR International Workshop, held in February 1997, provided the opportunity for regulatory authority and industry experts from Europe, Japan and the USA to share their experiences of designing safety evaluation programmes for specific product classes: colony stimulating factors, growth factors, hormones, interferons, interleukins, monoclonal antibodies for therapeutic use, and gene therapy products. Participants worked together to recommend those studies that should be considered for such safety evaluation, and those that may be unnecessary. These recommendations subsequently made a valuable contribution to the ICH guideline `Safety Studies for Biotechnological Products’, which was finalised at ICH 4 in Brussels in July 1997. The Workshop proceedings not only describe the recommendations but also provide the reader with an appreciation of the science behind safety evaluation strategies used by experts, the influence of different regulatory systems on these strategies, and the type of data required by both toxicologists and clinicians before they have sufficient confidence to administer pharmaceutical products of biotechnology to humans.

Free Download Human iPSC-derived Disease Models for Drug Discovery
English | 2023 | ISBN: 3031423488 | 574 Pages | PDF EPUB (True) | 31 MB
Since their development a decade ago, human induced pluripotent stem cells (iPSC) have revolutionized the study of human disease, given rise to regenerative medicine technologies, and provided exceptional opportunities for pharmacologic research. These cells provide an essentially unlimited supply of cell types that are difficult to obtain from patients, such as neurons or cardiomyocytes, or are difficult to maintain in primary cell culture. iPSC can be obtained from patients afflicted with a particular disease but, in combination with recently developed gene editing techniques, can also be modified to generate disease models. Moreover, the new techniques of 3 Dimensional printing and materials science facilitate the generation of organoids that can mirror organs under disease conditions. These properties make iPSC powerful tools to study how diseases develop and how they may be treated. In addition, iPSC can also be used to treat conditions in which the target cell population has been lost and such regenerative approaches hold great promise for currently untreatable diseases, including cardiac failure or photoreceptor degenerations.

Free Download Applications of Stem Cells and derived Exosomes in Neurodegenerative Disorders by Sadaf Jahan, Arif Jamal Siddiqui
English | PDF EPUB (True) | 2023 | 336 Pages | ISBN : 9819938473 | 29.8 MB
This book explores the therapeutic approaches of stem cells and stem cell-derived exosomes against neurodegenerative disorders (NDDs). The initial chapters introduce different neurodegenerative diseases and discuss the mechanistic aspects of their progression. The subsequent chapters cover strategies for the isolation, characterization, and differentiation of stem cells. In turn, the book reviews the protective role of stem cells against neurological disorders and examines regenerative approaches to treat neurological diseases using mesenchymal stem cells. The book also presents induced pluripotent stem cell (iPSC) technology for cellular therapy, drug screening, and in-vitro modeling of neurodegenerative diseases. Lastly, the book discusses the role of stem cells and derived exosomes as a novel therapeutic agent against Alzheimer’s and Parkinson’s disease and in associated signaling molecules involved in neuroprotection. This book is an invaluable source for researchers working towards understanding the potential of stem cell therapy in neurodegenerative disorders.

Free Download Plant-Derived Anticancer Drugs in the Omics Era
by Deepu Pandita
English | 2023 | ISBN: 1774912651 | 323 pages | True PDF | 29.95 MB
The current anti-cancer synthetic medicines are deemed inefficient and unsafe, state the editors of this new book. Plant-based lead molecules, however, such as taxol, camptothecin, podophyllotoxins, vinblastine, vincristine, homoharringtonine, and numerous other anticancer compounds from nature’s arsenal, are potentially safe and can be powerful alternatives that effectively fight against cancer.

Free Download Root-Derived Bicarbonate Assimilation in Plants
English | 2023 | ISBN: 9819941245 | 373 Pages | PDF EPUB (True) | 18 MB
This book summarizes the physiological effects of bicarbonate in plants and systematically introduces readers to a bidirectional isotope labeling tracer technique used to quantify the contribution of root-derived bicarbonate to total photosynthetic inorganic carbon assimilation in plants. This method helps to shed light on the role of dissolved inorganic carbon from the soil in overall photosynthesis, an aspect that has been underestimated or neglected entirely in the past.

Free Download Simon David Stein, "The Phonetics of Derived Words in English: Tracing Morphology in Speech Production "
English | ISBN: 3111023516 | 2022 | 227 pages | PDF | 7 MB
Effects of morphological structure on phonetic detail present us with two challenges. The empirical challenge is that some predictors have produced inconsistent effects. The theoretical challenge is that it is unclear where morpho-phonetic effects originate from. Do speakers decompose words into morphemes? Or can such effects also originate from non-decompositional structure?