Free Download and Medicine National Academies of Sciences, Engineering, "Therapeutic Development in the Absence of Predictive Animal Models of Nervous System Disorders: Proceedings of a Worksho"
English | ISBN: 0309455138 | 2017 | 94 pages | EPUB | 1060 KB
Compared with other disease areas, central nervous system (CNS) disorders have had the highest failure rate for new compounds in advanced clinical trials. Most CNS drugs fail because of efficacy, and the core issue underlying these problems is a poor understanding of disease biology. Concern about the poor productivity in neuroscience drug development has gained intensity over the past decade, amplified by a retraction in investment from the pharmaceutical industry. This retreat by industry has been fueled by the high failure rate of compounds in advanced clinical trials for nervous system disorders.