Tag: Target

Target Discovery and Validation Reviews and Protocols Volume 2 Emerging Molecular Targets and Treatment Options

Free Download Target Discovery and Validation Reviews and Protocols: Volume 2: Emerging Molecular Targets and Treatment Options By Mouldy Sioud, Marianne Leirdal (auth.), Mouldy Sioud (eds.)
2007 | 345 Pages | ISBN: 1588298906 | PDF | 7 MB
Target Discovery and Validation Reviews and Protocols, Volumes 1 and 2 review the most progressive and current methods for drug target discovery and validation. These volumes explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders.Volume 1 focuses on novel and innovative techniques, and presents the most up-to-date protocols available for maximizing the likelihood of achieving target-selective inhibition in vivo while minimizing side effects. The profound impact of genomics, proteomics and bioinformatics on target discovery is explored, and specific attention is given to the role of transgenic and knockout animals in functional genomics and target validation. Cancer researchers will find tremendous value in the molecular classification of breast cancers and the review of protocols for tumor antigens and cancer vaccines. The methods and protocols collected here, all reviewed by leading scientists and clinicians, present the practical details necessary for translating the enormous discovery potential of the genome into real therapeutic products.Volume 2 collects all the practical details required for efficient translation of discovered targets into real pharmaceutical drugs. Specific targets in cancers and autoimmunity are described and the potential of using siRNAs, antisense oligonucleotides and RNA aptamers in patients is reviewed. This volume explores the tremendous impact of the application of genotyping and gene expression profiling on the future of healthcare, and presents cutting-edge protocols to aid in bringing agents against specific targets closer to application in the clinic.Collectively, these volumes provide a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application. For researchers, an understanding of available methods aids in the creation of innovative experiments in the laboratory, and the successful translation of target discovery to real therapeutics.


Ielts Listening Target Band 7+

Free Download Ielts Listening Target Band 7+
Published 1/2024
MP4 | Video: h264, 1920×1080 | Audio: AAC, 44.1 KHz
Language: English | Size: 721.64 MB | Duration: 3h 10m
IELTS Listening is one of the four tests for IETLS exam. We have covered this portion of the test in this course.


Target London Bombing the Capital, 1915-2005

Free Download Target London: Bombing the Capital, 1915-2005 by Peter Reese
English | October 5th, 2011 | ISBN: 1848841221 | 240 pages | True EPUB | 4.71 MB
London was a target for Zeppelins and bombers during the First World War, for bombers, V1s and rockets in the Second, and for Cold War missiles and for terrorists in more recent times, yet rarely has the history of twentieth-century attacks on the capital been studied as a whole. Peter Reese, in this thought-provoking account, vividly describes how the destructive potential of aerial bombing and terrorist actions has increased and how Londoners have struggled to protect themselves and their city.


Target Underwear and a Vera Wang Gown Notes from a Single Girl’s Closet

Free Download Adena Halpern, "Target Underwear and a Vera Wang Gown: Notes from a Single Girl’s Closet"
English | 2006 | pages: 256 | ISBN: 1592402216 | EPUB | 0,3 mb
The story of a Philadelphia journalist’s life, told through the outfits she most loved, describes how she related fashion to her inner life and used clothes to conform, seduce, or hide her way through school, a series of relationships, and her career. 50,000 first printing.


Target in the Night

Free Download Ricardo Piglia, Sergio Waisman, "Target in the Night"
English | 2015 | pages: 288 | ISBN: 1941920160 | EPUB | 0,7 mb
"Ricardo Piglia may be the best Latin American writer to have appeared since the heyday of Gabriel García Márquez." – Kirkus Reviews


Hit the Target Eight Men Who Led the Eighth Air Force to Victory over the Luftwaffe [Audiobook]

Free Download Hit the Target: Eight Men Who Led the Eighth Air Force to Victory over the Luftwaffe (Audiobook)
English | ASIN: B01MXFCXBC | 2016 | 10 hours and 7 minutes | M4B@64 kbps | 276 MB
Author: Bill Yenne
Narrator: Corey M. Snow

Less than a month after the attack on Pearl Harbor, the US Army formed its first air force designated to operate overseas, the Eighth. Within four months they had set up base in England. Three months later they were bombing German targets in occupied Europe. The Eighth was the first bomber command on either side to commit to strategic daylight bombing. It was a major change in tactics – and the men of the Eighth paid the price in both lives and blood. But it was that very sacrifice that led the Allies to victory. Hit the Target introduces listeners to those who made the Eighth Air Force the formidable juggernaut it soon became – men of all ranks, from General Tooey Spaatz, the hard-driving founding commander, to Colonel Jimmy Doolittle, the hero who led the first air raid on Japan, to Maynard "Snuffy" Smith, the irascible first airman in Europe to be awarded the Congressional Medal of Honor, and Robert "Rosie" Rosenthal, who survived his time with the "Bloody Hundredth", which lost airmen at a horrifying rate, and who went on to serve as a prosecutor at the Nuremberg Trials. The story of the Mighty Eighth is told through these men, whose careers paralleled the early history of aviation and who helped to revolutionize airborne warfare and win World War II.